Do not waste kidneys

Waste not, want not.

As of the writing of this Editorial, the current JCI Editorial Board has evaluated approximately 7,000 manuscripts over the past 22 months for their suitability for publication in our journal. While many of you have received a negative decision on your manuscript, I suspect few are aware of the changes we have made to our review process to limit reviewers' requests for what is in our view unnec...

Waste not, weak not?

Waste Not , Want Not !

Computer systems are not the monolithic machines they used to be. In the early days of computer science (until the late 70s), most computer systems included exactly one component to perform a given task: one (type of) disc for persistence, one CPU for processing and one volatile RAM to hold intermediate data. Today, the architecture has developed into a heterogeneous landscape of components: di...

Do Not Copy Do Not Copy Do Not Copy Do Not Copy Do Not Copy Do Not Copy Do Not Copy Do Not Copy Do Not Copy

Design a clocked synchronous state machine with four inputs, G1–G4, that are connected to pushbuttons. The machine has four outputs, L1–L4, connected to lamps or LEDs located near the like-numbered pushbuttons. There is also an ERR output connected to a red lamp. In normal operation, the L1–L4 outputs display a 1-out-of-4 pattern. At each clock tick, the pattern is rotated by one position; the ...

Why do our kidneys get old?

The majority of the human population shows a decline in renal clearance with age and a loss of renal physiologic reserve. Kidneys are increasingly less able to deal with stressful challenges such as a salt or acid load. It is not clear what underlies this aging-related change and whether it is inevitable or can be modified in such a way as to preserve renal function throughout the life span. Th...